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Search for "radioactive probes" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.

Amyloid-β probes: Review of structure–activity and brain-kinetics relationships

Todd J. Eckroat,
Abdelrahman S. Mayhoub and
Sylvie Garneau-Tsodikova

Beilstein J. Org. Chem. 2013, 9, 1012–1044, doi:10.3762/bjoc.9.116

; radioactive probes; Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the central nervous system currently affecting ~5.4 million Americans, a number that could increase to 11–16 million by the year 2050. In the United States, AD represents the 6th leading cause of death

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Graphical Abstract

Figure 1: Structures of A. dyes originally used to stain Aβ and B. newer scaffolds explored for the developme...

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Scheme 1: General synthetic strategies (Gs) used to introduce A. ¹⁸F, B. ¹¹C, C. ^99mTc/Re, and D. ¹²³I and ¹²⁵...

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Scheme 2: A. Structures of radiolabeled chalcone analogues discussed. B.–D. Synthetic schemes for the prepara...

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Scheme 3: A. Structures of the radiolabeled flavone and aurone analogues discussed. B. Synthetic scheme for t...

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Scheme 4: A. Structures of the radiolabeled stilbene analogues discussed. B. Synthetic scheme for the prepara...

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Scheme 5: A. Structures of the diphenyl-1,3,4- and diphenyl-1,2,4-oxadiazoles discussed. B.,C. Synthetic sche...

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Figure 2: Structures of the radiolabeled benzothiazole analogues discussed.

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Scheme 6: A.–F. Synthetic schemes for the preparation of [¹¹C]56b, [¹¹C]56c, 57, 58a,b, 61, and [¹⁸F]65a–d.

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Scheme 7: A. Structures of the [Re]- and [^99mTc]-labeled benzothiazole analogues discussed. B.,C. Synthetic s...

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Figure 3: Structures of the radiolabeled benzoxazole analogues discussed.

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Scheme 8: A.–E. Synthetic schemes for the preparation of 94, [¹²³I]95e, 96–98.

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Figure 4: Structures of the radiolabeled benzofuran analogues discussed.

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Scheme 9: A.–E. Synthetic schemes for the preparation of 121, [¹²⁵I]122a, 123a,b, 125a,b, and 126.

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Scheme 10: A. Structures of the radiolabeled imidazopyridine analogues discussed. B. Synthetic scheme for the ...

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Scheme 11: Synthetic scheme for the preparation of the benzimidazole 146.

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Figure 5: Structures of the quinolines discussed.

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Scheme 12: Synthetic scheme for the preparation of the naphthalene analogues 152 and 160a,b.

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Scheme 13: A. Structures of the radiolabeled analogues resulting from the combination of various scaffolds. B.,...

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Scheme 14: A.–C. Synthetic schemes for the preparation of radiolabeled probes with unique scaffolds.

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Scheme 15: A. Structures of the oxazine-derived fluorescence probes discussed. B. Synthetic scheme for the pre...

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Figure 6: Structure of THK-265 (190).

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Scheme 16: Synthetic scheme for the preparation of quinoxaline analogue 191.

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Review

Published 28 May 2013

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